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VIP

VIP (Vasoactive Intestinal Peptide) is a 28-amino-acid neuropeptide abundant in brain, gut, and lungs, signaling via VPAC1/VPAC2/PAC1 receptors (Gs-coupled). Researched for neuroprotection, IBD, pulmonary hypertension, and autoimmune diseases—↓TNF-α 70%, vasodilation, and immune modulation. Natural hormone; synthetic for stability.

Roles: “Gut-brain axis master”—anti-inflammatory, bronchodilator, circadian regulator.

Mechanism

Anti-Inflammatory: ↓NF-κB, cytokines; ↑IL-10.
Neuroprotection: cAMP → CREB → BDNF.
Vasodilation: NO/PGI2 release.
Gut Motility: SMC relaxation.
Circadian: SCN clock gene modulation.

PK: IV/nasal/subQ; half-life 2min (native), analogs ~hours.

Research Evidence

Application	Studies/Effects
IBD/UC	Remission 60%, mucosa healing (Phase 2, Gut 2018).
Neuro (MS/PD)	↓Demyelination, neuroinflammation (EAE models).
Pulmonary	PVR ↓30% (PAH trials).
COVID/ARDS	Cytokine storm ↓ (compassionate).
Sleep/Circadian	Jet-lag reset (SCN studies).

Protocols (Research Contexts)

Goal	Dose (mcg/day)	Route/Frequency	Cycle
Gut (IBD)	100–500	Oral/nasal daily	8–12 weeks
Neuroprotection	50–200	Nasal BID	Ongoing
Pulmonary	200–1000	Inhaled/IV	Acute
Wellness	25–50	Nasal PM	Long-term

Analogs: Cyclized VIP (stability).
Stack: w/ KPV (MC synergy), BPC-157 (gut).

Benefits

Inflammation Control: Autoimmune, post-viral.
Gut-Brain: IBS, depression.
Cardio-Pulmonary: BP, asthma.
Sleep/Repair: Circadian reset.
Immunity: Th2 shift.

Side Effects & Safety

Common	Rare	Mitigation
Flushing, ↓BP	Tachycardia	Titrate, monitor HR
Nausea	None major	Nasal > IV

Profile: Safe chronic (asthma trials).

Comparisons

Peptide	Receptors	Primary Use	Half-Life
VIP	VPAC1/2	Gut/Neuro	Short
PACAP	PAC1	Migraine	Short
KPV	MC1R	Cytokine	Stable
Secretin	SCTR	Pancreatic	Short

Status

Research/Compassionate: Nasal sprays advancing.
UK: Clinic trials IBD/neuro.
Future: Phase 3 pulmonary.

Disclaimer: Research/clinical only.

Reviews

There are no reviews yet.

VIP

VIP