L-Glutathione 1500mg
L-Glutathione (GSH) is the body’s premier endogenous tripeptide antioxidant (glutamate-cysteine-glycine), neutralizing free radicals, detoxifying xenobiotics, and regenerating vitamins C/E. At 1500mg doses, it’s researched for anti-aging, liver support, immunity, and skin brightening—far beyond standard 500mg supplements.
Oral Challenge: Low bioavailability (10–20%) due to gut breakdown; 1500mg compensates via saturation. L-Glutathione/sublingual forms hit 80%+ absorption.
How It Works
- Core Functions:
- ROS Scavenging: GSH + GSSG cycle via GPx enzyme.
- Detox: Phase II conjugation (mercury, acetaminophen).
- Immune: T-cell proliferation, cytokine balance.
- Gene Regulation: Nrf2 activation → HO-1, SOD ↑.
- Depletion Causes: Aging, stress, pollution, booze—1500mg replenishes.
Pharmacokinetics: Peak plasma 1–2h; half-life 2–4h; 1500mg yields 200–400μM serum (optimal).
Research Evidence
| Benefit | Key Studies/Effects |
|---|---|
| Liver Protection | ↓ALT/AST 30% in NAFLD (Nutrients, 2017); acetaminophen OD antidote. |
| Skin Brightening | ↓Melanin 15–25% (Clin Cosmet Investig Dermatol, 2017); UV protection. |
| Anti-Aging | Telomere length ↑, wrinkles ↓ (Nutr Res, 2014). |
| Immunity | Flu duration -3 days; NK cells ↑ (Eur J Nutr, 2019). |
| Neuroprotection | Parkinson’s PD symptoms ↓ (animal/human pilots). |
- High-Dose (1500mg+): Japanese studies show oxidative stress ↓50%.
High-Dose 1500mg Protocols
| Goal | Daily Dose | Form/Timing | Cycle |
|---|---|---|---|
| Detox/Liver | 1500mg | Liposomal, split AM/PM | 4–8 weeks |
| Skin Glow | 1500–2000mg | Sublingual + topical | Ongoing |
| Immunity | 1000–1500mg | With Vit C 1g | Seasonal |
| Anti-Aging | 1500mg + NAC 600mg | AM fasted | 12 weeks on/4 off |
- Stack: NAC (precursor), Vit C (recycles GSH), selenium (GPx cofactor).
- Delivery: Liposomal > sublingual > reduced GSH > standard.
Benefits Breakdown
- Detox Mastery: Binds heavy metals; hangover/liver shield.
- Radiant Skin: Tyrosinase inhibition = even tone, anti-UV.
- Energy/Mitochondria: ROS ↓ → ATP ↑.
- Brain Fog Lift: Glutathione peroxidase protects neurons.
- Longevity: Nrf2 → sirtuins, autophagy.
Side Effects & Safety
| Common (Rare) | High-Dose Concerns | Mitigation |
|---|---|---|
| Bloating, cramps | Asthma trigger (inhaled) | Start 500mg, electrolytes |
| Sulfur smell | ↓Zinc (long-term) | Zinc 30mg/day |
- LD50: >5g/kg; safe up to 3000mg/day (studies).
- Contraindications: Sulfur allergy.
Comparisons: Forms & Doses
| Form | Absorption | 1500mg Effect |
|---|---|---|
| Liposomal | 80–90% | Optimal serum |
| Sublingual | 60–80% | Fast peak |
| Standard Oral | 10–20% | Baseline |
| IV | 100% | Clinical max |
Status & Optimization
- UK/EU: L-Glutathione OTC supplement; pharma-grade for IV.
- Synergies: w/ Milk Thistle (liver), ALA (recycle).
- Research Gap: More RCTs needed for skin/neuro claims.
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