Kisspeptin-10
Kisspeptin-10 (decapeptide: Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2) is the minimal active fragment of kisspeptin (KP), a KISS1R/GPR54 agonist that triggers GnRH release from hypothalamus → LH/FSH surge. Essential for puberty onset, fertility, testosterone, and researched for HPTA restart, libido, PCOS. Potent at nM doses; mimics natural pulsatile signaling.
Role: “Master regulator” of reproduction; metabolic links (energy balance).
Mechanism
- KISS1R Activation: ↑PLC/IP3 → GnRH neuron depolarization.
- Hormone Cascade: GnRH → LH/FSH → T/E2 surge (2–5x).
- Pulsatility: 10–60min half-life preserves cycles.
- Metabolic: Leptin-sensitive; appetite-fertility link.
PK: IV/subQ/nasal; t1/2 4min (bolus effects 1–2h).
Research Evidence
| Application | Studies/Outcomes |
|---|---|
| Hypogonadism | LH ↑400%, T +200% (single 1μg/kg IV, JCEM 2014). |
| PCT/Restart | HPTA recovery post-steroid (anecdotal + pilots). |
| PCOS | Ovulation induction (Phase 2). |
| Libido | Arousal + desire (central). |
| Metabolic | Insulin sensitivity via KNDy neurons. |
Protocols (Research)
| Goal | Dose (mcg/kg or total) | Route/Frequency | Cycle |
|---|---|---|---|
| T-Boost | 0.1–1μg/kg | SubQ 1–3x/day | 4–8 weeks |
| PCT Restart | 50–100mcg | Pulsed q2h x3 days | Post-cycle |
| Fertility | 1–10μg/kg | IV bolus | Monitored |
| Libido | 20–50mcg | Nasal PRN | As needed |
- Pulsing: Mimics natural 90–120min GnRH.
- Stack: w/ HCG (gonadal), Kisspeptin-54 (full-length).
Benefits
- Hormonal Restart: Non-suppressive T/LH.
- Fertility: Ovulation trigger.
- Libido/Mood: Upstream desire.
- Metabolic: Energy homeostasis.
- Puberty Models: GnRH axis.
Side Effects & Safety
| Common | Rare | Mitigation |
|---|---|---|
| Transient flush | OHSS (high ferti dose) | Titrate |
| Headache | None major | Clean profile |
Comparisons
| Peptide | Target | T-Surge | Pulsatile? |
|---|---|---|---|
| Kisspeptin-10 | KISS1R | 400% | Yes |
| HCG | LH-R | Direct | Steady |
| GnRH | GnRH-R | 200% | Yes |
| Clomid | E-R | Indirect | Oral |
Status
- Research Chemical: Phase 2 fertility (Tivorbex).
- UK: Clinical trials reproductive.
- Future: Male hypogonadism 2026+.
Disclaimer: Research-only; hormone monitoring essential.
| QUANTITY | 5mg, 10mg |
|---|
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