Ipamorelin
Ipamorelin is a pentapeptide GHRP (Aib-His-D-2Nal-D-Phe-Lys-NH2) and ghrelin mimetic that stimulates pituitary GH release via GHS-R1a with high selectivity—minimal cortisol/prolactin/lactate spikes vs. GHRP-6. Half-life ~2 hours; ideal for pulsatile GH/IGF-1 elevation in muscle growth, fat loss, recovery research.
Clean Profile: No hunger, desensitization-resistant.
Mechanism
- GHS-R1a: ↑[Ca2+]i → GH exocytosis.
- Pulse Mimic: 5–10x GH peaks (natural-like).
- No Off-Target: 14x more selective than GHRP-2.
- Synergy: Amplifies GHRH (CJC).
Research Evidence
| Effect | Studies/Outcomes |
|---|---|
| GH/IGF-1 | GH ↑9x, IGF-1 +1.5x (single 100mcg subQ, Endocrinol 1998). |
| Body Comp | Fat -14%, lean +9% (60 days, elderly, Int J Endocrinol). |
| Bone Density | BMD ↑ in GH-deficient (pilot). |
| Sleep/Recovery | Deep sleep ↑ via GH. |
Protocols (Research)
| Goal | Dose (mcg/dose) | Frequency/Route | Cycle |
|---|---|---|---|
| GH Pulse | 100–300 | 2–3x/day subQ | 8–12w on/4 off |
| Fat Loss | 100–200 | TID fasted | 12 weeks |
| Bulking | 200–400 | 3x/day w/ CJC | 12–16w |
| Recovery | 100 | Nightly | PRN |
- Recon: Bac water (5mg vial, 2ml = 250mcg/0.1ml).
- Stack: CJC no-DAC (GHRH synergy 10x).
Benefits
- Clean GH Boost: Pulsatile, physiological.
- Fat Metabolism: Lipolysis w/o catabolism.
- Recovery: Joints, tendons.
- Sleep Quality: Natural architecture.
- Elderly: Sarcopenia counter.
Side Effects & Safety
| Mild Common | Rare | Mitigation |
|---|---|---|
| Head rush, water | Prolactin ↑ (minimal) | Low dose start |
| Hunger (low) | None major | Cleanest GHRP |
Comparisons
| GHRP | Hunger | Cortisol | Selectivity |
|---|---|---|---|
| Ipamorelin | Low | Low | Highest |
| GHRP-2 | High | Mod | High |
| GHRP-6 | High | High | Mod |
| MK-677 | High | Mod | Oral |
Status
- Research Chemical: Widely studied.
- UK: Research protocols.
- No Approval: Clean alternative to pharma GH.
Disclaimer: Research-only; IGF-1 monitoring.
| QUANTITY | 5mg, 10mg |
|---|
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