DSIP
DSIP (Delta Sleep-Inducing Peptide; Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) is a nonapeptide discovered in 1977 (rabbit hypothalamus), promoting slow-wave sleep (SWS/deep sleep), reducing stress, and enhancing recovery. Research shows SWS ↑25–50%, cortisol ↓, pain tolerance ↑—ideal for insomnia, PTSD, chronic fatigue.
Unique: Mimics natural sleep architecture; no sedation/hangover.
Mechanism
- Sleep Regulation: Modulates GABA/A2A receptors, pineal melatonin.
- Stress Axis: HPA ↓ (CRH/ACTH/cortisol).
- Neuroprotection: Antioxidant, BDNF ↑.
- Pain/Recovery: Opioidergic, GH modulation.
PK: IV/nasal/subQ; half-life 15min (effects 6–15h).
Research Evidence
| Application | Studies/Effects |
|---|---|
| Insomnia | SWS ↑47%, continuity +30% (human EEG, Experientia 1981). |
| Stress/Anxiety | Cortisol ↓40%, mood ↑ (double-blind). |
| Pain | Threshold ↑, opiate withdrawal aid. |
| Athletic | Recovery acceleration (GH pulse). |
| Neuro | Epilepsy, stroke protection (rodents). |
Protocols (Research)
| Goal | Dose (mcg) | Route/Timing | Frequency |
|---|---|---|---|
| Sleep | 100–250 | Nasal/subQ 30min HS | Nightly PRN |
| Stress Recovery | 50–150 | IV/subQ PM | 5–10 days |
| Athlete | 200–500 | Post-WO + HS | Cycle 2w on/off |
| Chronic | 25–100mcg | Microdose daily | Long-term |
- Nasal: 100mcg/spray superior absorption.
- Stack: w/ Epitalon (pineal), DSIP + GH secretagogues.
Benefits
- Deep Sleep: Stage 3/4 restoration.
- Stress Buffer: Adrenal support.
- Recovery: Muscle, neural repair.
- Pain Modulation: Non-addictive.
- Hormonal: GH/testosterone optimization.
Side Effects & Safety
| Occasional | Rare | Notes |
|---|---|---|
| Mild headache | Vivid dreams | Transient; low tox |
| None major | None | 1000s subjects safe |
Comparisons
| Peptide | Sleep Focus | Stress Effect | Route Options |
|---|---|---|---|
| DSIP | SWS/Deep | High | Nasal/IV |
| Epitalon | Melatonin | Indirect | SubQ |
| Pinealon | Circadian | Neuro | Oral |
| Wada | REM | Low | Research |
Status
- Research Chemical: Soviet origins; no approval.
- UK: Nasal formulations research.
- Future: Insomnia trials potential.
Disclaimer: Research-only; sleep tracking advised.
| QUANTITY | 5mg, 10mg |
|---|
Reviews
There are no reviews yet.
Related products
Neurological and Cognitive Research
Neurological and Cognitive Research
Neurological and Cognitive Research
Neurological and Cognitive Research
Neurological and Cognitive Research
Neurological and Cognitive Research
Be the first to review “DSIP”