SERMORELIN
Sermorelin (GHRH 1-29 amide; 29-aa) is the first FDA-approved GHRH analog (1997, Geref), mimicking native growth hormone releasing hormone to stimulate pulsatile pituitary GH without supraphysiological spikes. Half-life ~10–20 minutes; amplifies natural GH/IGF-1 rhythms for anti-aging, recovery, body comp. Discontinued US manufacturing (2019 generics).
Purity: Preserves feedback loops vs. exogenous GH.
Mechanism
- GHRH Receptor: ↑cAMP → endogenous GH pulses.
- Pituitary Priming: Amplifies sleep/natural secretion.
- IGF-1 Mediation: Liver production ↑20–50%.
- No Desensitization: Native sequence.
Research Evidence
| Application | Studies/Outcomes |
|---|---|
| GH Deficiency | IGF-1 normalization 80% (pediatric/adult, JCEM). |
| Anti-Aging | Lean +2–5%, fat -10% (6–12mo, healthy elderly). |
| Bodybuilding | GH pulses 2–4x baseline (nightly dosing). |
| Sleep | Deep sleep architecture preserved/enhanced. |
Protocols (Research)
| Goal | Dose (mcg/night) | Route/Timing | Cycle |
|---|---|---|---|
| GH Restore | 200–500 | SubQ 30min HS | Continuous/cycled |
| Fat Loss | 100–300 | PM fasted | 12–16 weeks |
| Recovery | 100–200 | Post-WO + HS | PRN |
| Stack | 300mcg + Ipa 200mcg | GHRH/GHRP synergy | 8–12 weeks |
- Recon: Bac water (3mg vial common).
- Bedtime: Synergizes natural pulse.
Benefits
- Physiological GH: No carpal tunnel, edema.
- Body Comp: Lean mass, visceral fat ↓.
- Sleep/Recovery: Natural architecture.
- Bone Density: IGF-1 mediated.
- Clean Axis: Preserves HPTA.
Side Effects & Safety
| Mild (10%) | Rare | Mitigation |
|---|---|---|
| Site rxn, flush | Hypersensitivity | Rotate, low dose |
| Headache | None major | FDA pregnancy Cat B |
Comparisons
| GHRH | Half-Life | FDA Approved | Pulsatile |
|---|---|---|---|
| Sermorelin | 15min | Yes | Yes |
| CJC no-DAC | 30min | No | Yes |
| Tesamorelin | 30min | Yes (HIV) | Yes |
| CJC DAC | 7 days | No | No |
Status & Access
- Rx: Compounding pharmacies (US); research chemical.
- UK: Private research.
- Discontinuation: Manufacturing, not safety.
Disclaimer: Research/prescription; IGF-1 labs essential.
| QUANTITY | 5mg, 10mg |
|---|
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