TB-500
TB-500 (Thymosin β4 synthetic; Ac-LKKTETQ or full 43-aa) is a naturally occurring peptide (thymus-derived) that sequesters G-actin (43% cellular actin), promoting cell migration, angiogenesis, and anti-fibrosis. Research powerhouse for tendon/ligament repair, wounds, hair growth—healing 2–3x faster in models.
Key: Enables actin treadmilling for repair without inflammation.
Mechanism
- Actin Dynamics: G-actin pool → F-actin assembly at wounds.
- Migration: Keratinocytes, fibroblasts, endothelial cells.
- Angiogenesis: VEGF ↑, vessel formation.
- Anti-Fibrotic: ↓TGF-β, scarless healing.
- Neuro: Axon regrowth, anti-apoptotic.
PK: SubQ/IM; t1/2 ~48h; loading critical.
Research Evidence
| Application | Studies/Effects |
|---|---|
| Wounds | Closure 60% faster (diabetic mice, Ann N Y Acad Sci 2007). |
| Tendon | Collagen organization ↑, strength recovery (rat Achilles). |
| Heart | Post-MI remodeling, EF ↑ (Phase 2 safety). |
| Hair | Follicle stimulation (alopecia models). |
| Eye | Corneal repair (human trials). |
Protocols (Research)
| Phase | Dose (mg/week) | Frequency/Route | Duration |
|---|---|---|---|
| Loading | 7.5–10 | 2–3x subQ | Weeks 1–2 |
| Maintenance | 2–5 | 2x/week | 4–8 weeks |
| Local Injury | 2–4mg | Near site daily | Until healed |
| Hair/Skin | 2mg | SubQ scalp | 12 weeks |
- Recon: Bac water (5mg vial, 2ml).
- Stack: BPC-157 (vascular), GHK-Cu (skin).
Benefits
- Injury Repair: Tendons, muscles, ligaments.
- Wound Closure: Chronic ulcers, burns.
- Anti-Fibrotic: Scar reduction.
- Hair Growth: Follicle migration.
- Cardio/Neuro: Tissue preservation.
Side Effects & Safety
| Common (Mild) | Rare | Mitigation |
|---|---|---|
| Lethargy (load), site rxn | None major | Loading taper |
| Head rush | Theoretical angiogenesis | Cancer screen |
Comparisons
| Peptide | Actin Focus | Half-Life | Wound Speed |
|---|---|---|---|
| TB-500 | Primary | 48h | Fastest |
| BPC-157 | Vascular | 4h | Fast |
| GHK-Cu | Collagen | Variable | Skin |
| BPC/TB Blend | Combined | Mixed | Optimal |
Status
- Research Chemical: WADA-monitored.
- UK: Research protocols.
- Trials: Dry eye (RegeneRx Phase 3).
Disclaimer: Research-only; injury-specific.
| QUANTITY | 5mg, 10mg |
|---|
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