Selank
Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) is a synthetic heptapeptide analog of tuftsin (natural immunomodulator), developed in Russia (1990s, V. Ashmarin). Acts as anxiolytic + nootropic via enkephalin enhancement, BDNF ↑, and GABA modulation—anxiety ↓30–50% without sedation. Nasal delivery crosses BBB rapidly.
Dual Action: Fast-acting (5min) + cumulative neuroplasticity.
Mechanism
- Bdnf/TrkB: Neurogenesis, LTP ↑.
- Enkephalins: Anxiety buffer (no tolerance).
- GABA/5HT: Serotonin modulation.
- Immune: T-cell balance, IL-6 ↓.
- Stress: HPA normalization (cortisol ↓).
PK: Nasal → CSF 80% bioavailability; t1/2 2min (effects 12h).
Research Evidence (Russian + Global)
| Application | Studies/Effects |
|---|---|
| Anxiety/Stress | HAM-A ↓47% vs. placebo (60 patients, Neurosci Behav Physiol 2008). |
| Cognition | Memory/learning ↑25%, attention sustained (ADHD models). |
| Immune | Acute infections ↓ duration 2x. |
| Neuroprotect | Stroke recovery, BDNF ↑ (rat MCAO). |
| COVID/Anxiety | Cytokine + stress reduction (Russian pilots). |
Protocols (Research)
| Goal | Dose (mcg/day) | Route/Frequency | Cycle |
|---|---|---|---|
| Anxiety | 200–400 | Nasal 2–3x/day | 10–14 days |
| Cognition | 300–600 | AM + mid-day | 2–4 weeks |
| Stress Recovery | 100–300 | TID PRN | Acute |
| Stack | 300mcg + Semax | Nootropic duo | 14 days |
- Nasal: 0.15% spray (1–2 sprays/nostril).
- Semax Pair: BDNF synergy.
Benefits
- Rapid Anxiety Relief: 15min onset.
- Cognitive Edge: Focus, memory.
- Stress Resilience: Cortisol buffer.
- Immune Support: Viral resilience.
- Clean: No dependence/sedation.
Side Effects & Safety
| Minimal | Rare | Notes |
|---|---|---|
| Mild nasal irritation | None | Safer than benzos |
Comparisons
| Peptide | Anxiolytic | Cognitive | Nasal? |
|---|---|---|---|
| Selank | High | High | Yes |
| Semax | Mod | High | Yes |
| Selank vs. Phenibut | Natural | No withdrawal | Superior |
| Noopept | Low | High | Oral |
Status
- Russia: Rx (Selank spray).
- Research Chemical: Nasal globally.
- UK: Research/clinic.
Disclaimer: Research-only; mood tracking advised.
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