GHK-Cu
GHK-Cu is a naturally occurring tripeptide-copper complex (peak levels age 20–25, decline 60%+ by 60), binding copper ions for collagen/elastin synthesis, antioxidant defense, and tissue remodeling. Discovered 1973 (Loren Pickart), researched for wound healing, wrinkles, hair growth—collagen ↑70%, MMP-9 ↓50% in vitro.
Copper Magic: Cu2+ delivery remodels ECM without toxicity.
Mechanism
- Collagen/Elastin: TGF-β ↑, fibroblasts activated.
- Antioxidant: SOD mimic, ROS scavenging.
- Anti-Inflammatory: ↓TNF-α, IL-6, NF-κB.
- Gene Reset: 4000+ aging genes reversed (epigenetic).
- Angiogenesis: VEGF/HGF modulated.
PK: Topical/subQ; penetrates stratum corneum.
Research Evidence
| Application | Studies/Effects |
|---|---|
| Wrinkles/Skin | Collagen I/III ↑350%, thickness +70% (12w topical, Biofactors 2015). |
| Wounds | Closure 2x faster, scars ↓ (diabetic ulcers). |
| Hair Growth | Follicle size ↑, DHT block (MPB models). |
| Anti-Aging | Aging gene signature reversed (mass spec). |
| Lung Fibrosis | IPF models: remodeling without progression. |
Protocols (Research)
| Goal | Dose/Form | Frequency/Method | Duration |
|---|---|---|---|
| Skin Youth | 0.5–2% cream | BID topical | 8–12 weeks |
| Wounds/Scars | 1–5mg subQ | Daily near site | 4–6 weeks |
| Hair | 1mg scalp serum | Daily massage | 12+ weeks |
| Systemic | 1–2mg subQ | 3x/week | Cycles |
- Stack: BPC/TB (repair), Argireline (wrinkles).
- Serum: DIY 0.1–1% Cu-peptide.
Benefits
- Skin Rejuvenation: Firmness, elasticity, pigmentation.
- Hair Restoration: Density/thickness.
- Wound Healing: Clean granulation.
- Anti-Inflammatory: Acne, rosacea.
- Longevity: Systemic remodeling.
Side Effects & Safety
| Mild Common | Rare | Notes |
|---|---|---|
| Transient redness | Cu overload (chronic high) | Patch test; <5mg safe |
Comparisons
| Peptide | Copper? | Skin Potency | Hair Effect |
|---|---|---|---|
| GHK-Cu | Yes | Highest | Strong |
| GHK | No | Lower | Mod |
| BPC-157 | No | Repair | Indirect |
| TB-500 | No | Migration | Wound |
Status
- Cosmetic: OTC serums (0.1–1% Cu).
- Research: Inj for systemic.
- UK: Widely available topical.
Disclaimer: Topical OTC; inj research-only.
| QUANTITY | 50mg, 100mg |
|---|
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